The National Testing Agency (NTA) conducted the CUET PG 2026 Bioinformatics (SCQP06) examination on March 13, 2026, during Shift 2 from 12:30 PM to 02:00 PM.
Students who appeared for the exam reported that the overall difficulty level of the paper was moderate. CUET PG 2026 Bioinformatics Question Paper with Solutions PDF is available here for download. The marking scheme is +4 for correct answers and -1 for wrong answers, totaling 300 marks.
CUET PG 2026 Bioinformatics Question Paper with Solutions PDF
Question 1:
Which algorithm is used for performing Global Sequence Alignment?
- (A) Smith–Waterman Algorithm
- (B) Needleman–Wunsch Algorithm
- (C) BLAST Algorithm
- (D) FASTA Algorithm
Question 2:
What is the primary difference between PAM and BLOSUM scoring matrices?
- (A) PAM matrices are based on global alignments, while BLOSUM matrices are based on local alignments
- (B) PAM matrices are used only for DNA sequences, while BLOSUM matrices are used for proteins
- (C) PAM matrices are derived from highly divergent sequences, while BLOSUM matrices use closely related sequences
- (D) PAM matrices are heuristic methods, while BLOSUM matrices use dynamic programming
Question 3:
Which biological database is considered a curated, secondary database for protein sequences?
- (A) GenBank
- (B) UniProtKB/Swiss-Prot
- (C) EMBL
- (D) DDBJ
Question 4:
In the Michaelis-Menten equation, what does the constant \(K_m\) represent?
- (A) Maximum reaction velocity
- (B) Substrate concentration at half of \(V_{max}\)
- (C) Enzyme concentration
- (D) Rate of enzyme degradation
Question 5:
Which amino acid is responsible for forming disulfide bridges in a protein structure?
- (A) Glycine
- (B) Cysteine
- (C) Lysine
- (D) Alanine
Question 6:
What is the specific function of the BLASTn program?
- (A) Compare protein sequences
- (B) Compare nucleotide sequences
- (C) Predict protein structure
- (D) Align protein structures
Question 7:
Which tool is most commonly used for Multiple Sequence Alignment (MSA)?
- (A) BLAST
- (B) ClustalW
- (C) FASTA
- (D) Needleman–Wunsch
Question 8:
The p53 protein is primarily known for which cellular role?
- (A) DNA replication
- (B) Tumor suppression
- (C) Protein synthesis
- (D) Cell membrane transport
Question 9:
Which molecular technique is used to detect specific mRNA molecules in a sample?
- (A) Southern Blot
- (B) Northern Blot
- (C) Western Blot
- (D) PCR
Question 10:
In computer science, what does the Markov Property assume about future states?
- (A) Future states depend on all previous states
- (B) Future states depend only on the current state
- (C) Future states depend only on the initial state
- (D) Future states are completely random
Question 11:
Which database serves as the main archive for 3D macromolecular structures?
- (A) GenBank
- (B) Protein Data Bank (PDB)
- (C) UniProt
- (D) EMBL
Question 12:
What is the purpose of Emulsion PCR (ePCR) in Next-Generation Sequencing?
- (A) To sequence DNA directly without amplification
- (B) To amplify individual DNA fragments in isolated microreactors
- (C) To detect proteins in sequencing samples
- (D) To separate RNA molecules from DNA
Question 13:
Which component is strictly part of a Microprocessor System Unit, excluding peripherals?
- (A) Keyboard
- (B) Monitor
- (C) CPU
- (D) Printer
Question 14:
How does a 2D array differ from a 1D array in a programming language like C++?
- (A) A 2D array stores characters only
- (B) A 2D array has rows and columns
- (C) A 2D array stores only integers
- (D) A 2D array cannot store multiple values
Question 15:
Which type of bond characterizes the primary structure of DNA?
- (A) Hydrogen bond
- (B) Ionic bond
- (C) Phosphodiester bond
- (D) Disulfide bond
CUET PG 2026 Bioinformatics Preparation
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