IISER Bhopal Develops Method to Tag Protein Chemical For Easier Drug Discovery, Names it BHoPAL; Check Details Here

Content Curator

The Indian Institute of Science Education and Research Bhopal has developed a new method named BHoPAL which allows attaching chemical tags to proteins.

IISER Bhopal Develops Method to Tag Protein Chemical For Easier Drug Discovery Names it BHoPAL

New Delhi: The Indian Institute of Science Education and Research Bhopal has developed a method to attach chemical tags to proteins. This crucial step towards drug development was taken by Dr. Dimpy Kalia Assistant Professor in IISER Bhopal who supervised her PhD students, Chhaya Singh, Mudassar H Mir, and Sangeeta Parma on this project.

This technique will enable the addition of chemical groups in the field to precise the locations on a protein without compromising the protein’s functionality. This finding was published in the journal Nature Communications.

All About the IISER Bhopal’s Method for Protein Chemical Tagging

The technology is called “Baylis Hillman orchestrated Protein Aminothiol Labelling (BHoPAL)” which simplifies the attaching of chemical agents to proteins and shows promise for disease diagnosis, drug development, cellular imaging, and exploring molecular drug-target interactions.

Dr Dimpy Kalia, assistant professor, Department of Chemistry at IISER Bhopal said, “Proteins are cellular entities that are very important in all cellular functions. Protein dysfunction results in major life-threatening diseases like Alzheimer’s disease. Hence these effective approaches to studying proteins in cells for developing therapeutic approaches are important.”

This process not only attaches proteins to fluorescent chemical tags for visualization of cells but also links drugs to antibody proteins for selective drug delivery to diseased cells helps studies focused on understanding cellular functions and prevents undesirable side-effects of drugs.

Check: IISER Bhopal Develop Material to Break Down Chemical Warfare Agents like Mustard Gas; Check Details Here